Abstract Tissue engineering is a new and interdisciplinary science whose purpose is to make a suitable replacement for the damaged tissue in the patient's body. And at the same time, it has the task of bearing the load. In this research, the polycaprolactone-hardstonite scaffold was made by 3D printer and melt deposition method, and in order to eva‎luate the fabricated scaffolds, various tests including XRD, SEM observation, biodegradability, bioactivity and compressive strength test were performed. The compressive strength of the 0, 10, 20 and 30% scaffolds is equal to 3.1, 3.5, 5.7 and 5.0 MPa, respectively, and their elastic modules was also measured equal to 0.24, 0.29, 0.22 and 0.20 MPa. The pressure test results shows that, the most optimal mechanical properties are related to the scaffold with PCL-20%HT. In order to eva‎luate the bioactivity and biodegradability of the scaffolds, SBF and PBS solutions were used for 2, 3, 4 and 5 weeks, respectively. The results of the bioactivity test and its comparison with some other researchers' results showed that the bioactivity behavior of hardstonite is weaker than other bio ceramics and hydroxyapatite deposits were not formed well in weeks 2, 3 and 4 and only in the fifth week Considerable hydroxyapatite is formed. On the other hand, the scaffolds have favorable biodegradability, so that the scaffold with PCL-20%HT, after being placed in the body simulating solution for 5 weeks, had a weight loss of about 6%. However, because hardstonite is a strong ceramic phase, its use in bone tissue engineering covers its relatively weak bioactivity. Finally, by examining all the results, the most optimal composition for the composite scaffold is PCL-20%HT.

محمد خدائي

تقي اصفهاني , مهدي مهدي خاني