Compared to traditional invasive techniques for wound closure, photocrosslinkable surgical adhesives with antibacterial properties offer significant advantages. These include ease of application, a controllable and efficient curing reaction, reduced risk of pain and infection, and effective leakage prevention. In the present study, the synthesis and eva‎luation of three different groups of antibacterial UV-curable bioadhesives derived from renewable resources has been conducted. The first part of this study introduces a novel soybean oil-based nonisocyanate polyurethane prepolymer for use in photocurable bioadhesives. The prepolymer, a hydroxyurethane functionalized with methacrylate and quaternary ammonium salts (QAs), was characterized through spectroscopic methods. The final UV-curable bioadhesives, synthesized via thiol-ene-methacrylate click-photopolymerization, incorporated the aforementioned prepolymer, limonene as a reactive diluent, a tetra-functional thiol crosslinker, and a photoinitiator... In the second part, a soybean oil-based polyhydroxyurethane with free hydroxyl groups was prepared and functionalized via reaction with itaconic anhydride. Tannic acid (TA) a bio-based polyphenolic compound selected as an adhesion promoter and antibacterial agent underwent a partial methacrylation reaction to obtain tannic acid methacrylate (TAMA). Combination of these compounds at proper composition with a photoinitiator, multifunctional thiol, and a reactive diluent led to the preparation of thiol-ene photopolymerizable system. FTIR and 1H-NMR spectroscopic methods were utilized to characterize these materials. The potential applicability of this light-curable system as an antibacterial bioadhesive was investigated through various assays... In the third study, a novel nonisocyanate polyurethane prepolymer based on poly(ethylene glycol) diglycidyl ether and functionalized with quaternary ammonium compounds and photopolymerizable unsaturated groups, was synthesized through gentle synthetic steps. The final bioadhesives were produced through UV-light-induced thiol-ene photopolymerization, using the synthesized prepolymer, limonene as a reactive diluent, a multifunctional thiol crosslinker, and TPO as a UV initiator... Consequently, these materials are promising candidates for bioadhesive applications.

سعيد نوري خراساني , حميد يگانه اولادآدم

ايرج محمد پور بلترك

محمد ديناري , افسانه فخار , غلامعلي كوهمره