بررسي و ارزيابي خواص مكانيكي و زيستي داربست نانو كامپوزيتي Ag-ZSM-5 PCl /بارگذاري شده با داروي لووفلوكساسين500 (LEVOFLOXACINE 500) توليد شده به روش چاپ سه بعدي جهت كاربردهاي مهندسي بافت استخوان

Abstract: Due to the bodyʹs inability to repair large bone injuries, tissue engineering using three-dimensional scaffolds is employed as an alternative environment for cell growth. In this research, porous scaffolds made of polycaprolactone (PCL) an‎d silver-coated zeolite na-noparticles were fabricated using the 3D printing method. These scaffolds possessed two macroporous (500-600 micrometers) an‎d microporous sizes with 70% porosity, suitable for angiogenesis an‎d bone growth. The results showed that the fabricated composite scaffolds have good mechanical flexibility an‎d do not fracture under force. Additionally, the pres-ence of silver-coated zeolite nanoparticles imparted strong antibacterial properties to the scaffold, which was confirmed by the formation of an inhibition zone in the bacterial cul-ture medium. Furthermore, these nanoparticles increased the scaffoldʹs biocompatibility by up to 60%. The presence of composite components an‎d the uniform distribution of nano-particles were confirmed by X-ray diffraction (XRD) analysis, ultraviolet spectroscopy (UV-Vis), an‎d scanning electron microscopy (SEM) images, respectively. By comparing mechanical properties such as Youngʹs modulus, the composite sample (20% zeolite with 80% polycaprolactone) was introduced as the optimal sample for application in bone tissue engineering, which was produced via the fused deposition modeling (FDM) 3D printing method to create the desired scaffold for bone extracellular ma-trix production

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