سنتز و مشخصه‌يابي سامانه دارورسان PVP-CuS@ZIF-90/CCM و كاربرد آن در دارورساني هدفمند: بررسي رهايش وابسته به pH داروي كوركومين در محيط برون‌تني

In recent years, the design of smart drug delivery systems with controlled an‎d targeted release capabilities has attracted considerable attention. Curcumin is recognized as a bioactive compound with anticancer, anti-inflammatory, an‎d antibacterial properties; however, its poor solubility, limited stability, an‎d low bioavailability have restricted its clinical application. In this study, a pH-sensitive hybrid drug delivery system based on a ZIF-90 metal–organic framework modified with polyvinylpyrrolidone-coated copper(II) sulfide nanoparticles (PVP-CuS@ZIF-90) was synthesized an‎d utilized for curcumin loading. The structural an‎d physicochemical properties of the synthesized samples were characterized using FTIR, XRD, FE-SEM, EDAX, TGA, an‎d zeta potential measurements. The results confirmed the formation of the ZIF-90 framework, stabilization of CuS nanoparticles within the structure, an‎d effective curcumin loading without disruption of the crystalline framework. In vitro drug release studies demonstrated that the PVP-CuS@ZIF-90/CCM system exhibited a pH-sensitive biphasic release pattern. After 48 hours, the release percentage was 52.52% at acidic pH (4.7) an‎d 27.93% at neutral pH (7.4), which can be attributed to the structural stability of the framework under neutral conditions an‎d its partial degradation in acidic environments. This behavior suggests potential applicability in targeting tumor microenvironments. MIC an‎d MBC assays revealed that curcumin loading significantly enhanced antibacterial activity. Furthermore, MTT assay results on normal L929 cells an‎d cancerous MCF-7 cells indicated that the synthesized system exhibited good biocompatibility toward normal cells at low an‎d moderate concentrations, while exerting a significant inhibitory effect on cancer cells.

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حسن حداد زاده , محمد ديناري