پديد آورنده :
زماني، مائده
عنوان :
تهيه و ارزيابي نانو الياف پلي كاپر ولاكتون حاوي مترونيدازول جهت رهايش كنترل شده دارو در درمان بيماري هاي پريودنتال
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
شيمي نساجي و علوم الياف
محل تحصيل :
اصفهان : دانشگاه صنعتي اصفهان، دانشكده نساجي
صفحه شمار :
دوازده، 126، [II] ص: مصور، جدول، نمودار
يادداشت :
ص. ع. به: فارسي و انگليسي
استاد راهنما :
محمد مرشد، ژاله ورشوساز
توصيفگر ها :
الكتروريسي نانو الياف , مواد آنتي ميكروبيال , محلول هاي الكتروريسي
تاريخ نمايه سازي :
22/7/1387
استاد داور :
حسين توانايي، محمد رضوي
چكيده فارسي :
به فارسي و انگليسي : قابل رويت در نسخه ديجيتال
چكيده انگليسي :
AbstractIn this thesis from poly caprolactone which is a biodegradable polymer nanofiberscontaining metronidazole benzoate were electrospun and evaluated for periodontaldiseases Solutions of 9 5 11 5 w v poly caprolactone and 5 15 w wmetronidazole benzoate in a mixture of dichloromethane and N N dimethylformamidewith the ratios of 90 10 80 20 and 70 30 were prepared and the nanofibers wereproduced by electrospinning technique Scanning electron microscopy SEM wasused to investigate the effect of solvents ratios and polymer drug concentrations onthe morphology and average diameter of the electrospun nanofibers In order to studythat no chemical interaction between polymer and drug has taken place FTIRspectrums were evaluated DSC results were also utilized to investigate the physicalstructure and probable chemical interaction of the polymer and drug Drug releasewas studied in a phosphate buffer medium with pH 7 4 The amount of drug dissolvedin this medium was determined by using the UV spectroscopy Results showed thatincreasing DCM DMF ratio will lead to a decrease in the solution conductivity and anincrease in the solution viscosity as well as the nanofiber diameter Also increasingthe metronidazole benzoate concentration will lead to an increase in the solutionconductivity and a decrease in the solution viscosity as well as the nanofiber diameter The results showed that the drug release rate is affected by the solvents ratio as wellas the polymer drug concentrations In webs with appropriate thickness the burstrelease was low and drug release was prolonged to 19 23 days Metronidazolebenzoate was released according to the fickian diffusion mechanism Conclusively poly caprolactone electrospun nanofibers web can release metronidazole benzoate ina controlled manner and drug loaded nanofibers can be used as a locally controlleddelivery system for metronidazole benzoate in periodontal diseases
استاد راهنما :
محمد مرشد، ژاله ورشوساز
استاد داور :
حسين توانايي، محمد رضوي
