پديد آورنده :
مرداني، الهام
عنوان :
استخراج اسيدچرب ضد سرطان گامالينولنيك اسيد با دي اكسيد كربن فوق بحراني به روش نيمه پيوسته از بذرگل گاوزبان
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
مهندسي شيمي
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان،دانشكده مهندسي شيمي
صفحه شمار :
پانزده،111ص.:مصور،جدول،نمودار
استاد راهنما :
محمدقريشي،علي اكبر دادخواه
توصيفگر ها :
سرطان سينه , اسيدهاي چرب ضروري , طراحي سطح پاسخ
تاريخ نمايه سازي :
4/3/89
استاد داور :
حسن قاضي عسگر،محمدرضا احساني
تاريخ ورود اطلاعات :
1396/09/29
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
Extraction of Gamma Linolenic Acid as an anti cancer fatty acid from the Echium amoenum seed oil by Supercritical CO2 using semicontinuous method mardanielham@yahoo com Submitted 7 Mar 2010 Department of Chemical Engineering Isfahan University of Technology Isfahan 84156 83111 Iran Assoc Prof Seyyed Mohammad Ghoreishi ghoreishi@cc iut ac ir Assist Prof Ali Akbar Dadkhah dadkhah@cc iut ac ir Abstract Echium amoenum Fisch C A Mey Boraginaceae that grows in the northern mountains of Iran is the source of very valuable essential fatty acids such as gamma linolenic acid GLA and stearidonic acid SDA that are mainly used in the pharmaceutical medicinal and dietary applications GLA and SDA are polyunsaturated fatty acids which are used to destroy tumor cells including breast prostate and pancreatic cancers without harming normal cells The common technique to extract oil from seeds is the conventional method such as Soxhlet with organic solvents such as n hexane and petroleum ether But the pharmaceutical and medicinal applications led to the need of developing better methods of extraction and purification without utilization of toxic organic solvents Therefore in this study essential fatty acids containing linoleic alpha linolenic gamma linolenic and stearidonic acid were extracted from Echium amoenum Boraginaceae seed oil via supercritical carbon dioxide and the results were compared with conventional Soxhlet method The Response Surface Methodology RSM was used to optimize the effective extraction parameters The chemical composition of recovered oil was analyzed by polar and non polar GC columns The experimental results of this study indicated that echium seed contained 25 wt oil and 92 as the maximum extraction recovery of oil was achieved at optimal operating conditions 43 C 280 bar 1 5 ml min 25 min static time and 130 min dynamic time using pure CO2 Applying 2 5 and 5 mole ethanol as a modifier at similar operating conditions enhanced the recovery to 96 and 112 respectively The statistical analysis demonstrated that all linear terms except static time quadratic of temperature pressure and dynamic time as well as the interactions between pressure and temperature and static and dynamic times have significant effects on oil yield The results indicated that supercritical fluid extraction is a viable technique for separation of constituents such as palmitic acid 6 7 stearic acid 3 4 oleic acid 12 13 linoleic acid 19 20 alpha linolenic acid 40 41 gamma linolenic acid 7 8 and stearidonic acid 8 9 Keywords Echium amoenum Gamma linolenic acid Supercritical extraction breast cancer Essential fatty acid Response Surface design
استاد راهنما :
محمدقريشي،علي اكبر دادخواه
استاد داور :
حسن قاضي عسگر،محمدرضا احساني
