پديد آورنده :
دوزنده، فاطمه
عنوان :
ساخت دو نوع حسگرا الكتروشيميايي بر پايه كمپلكس زوج يون جهت اندازه گيري داروهاي فناز و پيريدين هيدروكلريد و بنتاهيستين دي هيدروكلريد
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
شيمي تجزيه
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي
صفحه شمار :
[چهارده]،98ص.: مصور،جدول،نمودار
يادداشت :
ص.ع.به فارسي و انگليسي
استاد راهنما :
علي اصغر انصافي
استاد مشاور :
بهزاد رضايي
توصيفگر ها :
حسگر غشايي , الكتروسيم پوشش داده شده
تاريخ نمايه سازي :
15/6/89
استاد داور :
تقي خياميان، محمد تقي جعفريان
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
Preparation and Construction of Potentiometric Sensors Based On Ion Pair Complex for Determination of Phenazopyridine Hydrochloride and Betahistine Dihydrochloride Fatemeh Doozandeh Doozandeh 2007@yahoo com 7 April 2010 Department of chemistry Isfahan University of Technology Isfahan 84156 83111 Iran Degree M Sc Language Farsi Prof A A Ensafi ensafi@cc iut ac ir Abstract In the first part a new ion selective electrode based on potentiometric method was developed for the determination of phenazopyridine PZP The membranes incorporate based on interaction of N N pyromellitoyl bis L tyrosine dimethyl ester with PZP The best performance was obtained with the electrode having a membrane composition w w of PBTDE 1 9 PVC matrix 27 2 sodium tetraphenylborate NaTPB as an ion excluder 5 4 and dioctylsebacate DOS 65 5 and The sensors display stable and linear response with a slope of 61 1 mV decade 1 at pH 1 0 4 5 for the PZP concentration in the range of 1 0 10 2 7 0 10 6 mol L 1 and with a detection limit of 6 0 10 6 mol L 1 of PZP The electrode shows fast response time Application of this potentiometric sensor for the PZP determination in pharmaceuticals urine blood serum samples is reported without especial pretreatment In the second parta coated wire betahistine selective electrode based on the incorporation of a betahistine tetraphenylborate ion pairin a poly vinylchloride coating membrane was constructed This electrode has a linear dynamic range between 1 0 10 1 8 0 10 6 mol L 1 betahistine with a near nernstian slope of 29 7 mV decade 1 and a detection limit of 5 9 10 6 mol L 1 The potentiometric response is independent of the pH of the solution in the pH range 3 9 9 0 The proposed sensor displayed good selectivities over a variety of other organic and inorganic compounds because Selectivity coefficient data for some common inorganic cations sugars amino acids and the components of the mixed drugs investigated show negligible interference The electrode shows easy construction low cost fast response time within 10s and can be used for a period of 75 days without significant change in its performance characteristics Application of this potentiometric sensor for the betahistine determination in pharmaceuticals urine and blood serum samples is reported with satisfactory results Key Words Potentiometric sensor Phenazopyridine hydrochloride Coated wire electrode Betahistine dihydrochloride
استاد راهنما :
علي اصغر انصافي
استاد مشاور :
بهزاد رضايي
استاد داور :
تقي خياميان، محمد تقي جعفريان
