5693

5315

كارشناسي ارشد

شيمي معدني

اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي

1389

[ده]،79ص.: مصور،جدول،نمودار

ص.ع.به فارسي و انگليسي

حسن حدادزاده، مونا تسليمي

علي اكبر دهنو خلجي، افشين فصيحي

21/12/89

حسين چيني فروشان، كاظم كرمي

شيمي

ID5315

به فارسي و انگليسي:قابل رويت در نسخه ديجيتالي

Piroxicam complexes of Copper II Zinc II and Nickel II Interaction of trans Cu Pir 2 THF 2 with DNA Zahra Jannesari Zh janesari@yahoo com October 27 2010 Department of Chemistry Isfahan University of Technology Isfahan 84156 83111 Iran Degree M S Language Farsi H Hadadzadeh Assoc Prof hadad@cc iut ac ir M Salimi Assistant Prof salami mona@yahoo com Abstract Non steroidal anti inflammatory drugs NSAIDs are among the most frequently used medicinal drugs They are utilized primarily as analgesics anti inflammatories and antipyretics Piroxicam is a non steroidal anti inflammatory drug used to relieve the symptoms of rheumatoid and osteoarthritis primary dysmenorrhoea postoperative pain and act as an analgesic especially where there is an inflammatory component In addition piroxicam has nonpharmacological application too Copper piroxicam complexs can catalyse the elimination of superoxide radicals In this work pharmacological application of piroxicam was studied Recently It had been found that the Cu complexes of piroxicam is itself more active as anti inflammatory agent than its parent compound Hence one of the goals of this project is to synthesis piroxicam chelates with Ni II Cu II and Zn II ions From the structural data it is possible to discern how it is coordinated to the metal ions then to hypothesize how it can be coordinated in biological systems The study aims also to determine the coordination capacity of piroxicam that incorporates served binding sites via the IR UV Vis X ray and NMR All techniques reveal that piroxicam behaves as a monoanionic bidentate ligand coordinated to the metal ions through the pyridyl N and carbonyl O of the amide Chelates have distorted octahedral geometrical structures Piroxicam is not only used as anti inflammatory and analgesic agent but also exhibit chemopreventive and chemosuppressive effects on various cancer cell lines Piroxicam exerts its anticancer effects by inhibiting both at the protein level and or at the transcription level Cu II complexes of this NSAID show better anti cancer effects than the bare drug CD spectrum is a sensitive reporter of any alteration in the DNA backbone We have therefore used CD spectroscopy to identify the backbone distortions in the DNA obtained upon binding of Cu II piroxicam complex and Circular dichroism CD spectroscopy showed that the binding of Cu II piroxicam with DNA results in DNA backbone distortions Even though the molecular mechanism behind piroxicam complexes principal function i e as analgesic and anti inflammatory agents is quite well understood it is not clear exactly how they exert their anticancer effects Anticancer effects of these drugs have been implicated to occur both by the cyclooxygenase COX dependent and COX independent pathways Key Words Non steroidal anti inflammatory drugs Piroxicam complexes Drug DNA interaction Anticancer Circular dichromism Antiinflammatory Distortion Analgesics

حسن حدادزاده، مونا تسليمي

علي اكبر دهنو خلجي، افشين فصيحي

حسين چيني فروشان، كاظم كرمي