5847

5462

كارشناسي ارشد

شيمي آلي

اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي

1389

[يازده]،99ص.: مصور،جدول،نمودار

ص.ع.به فارسي و انگليسي

عبدالرضا حاجي پور

10/2/90

عبدالحسين دباغ، امير عبدالملكي

شيمي

ID5462

به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي

101 Synthesis and characterization of coumarins 1 amidoalkyl 2 naphtols and amino nitrils using ionic liquid 3 carboxypyridinium hydrogen sulfate under green conditions Samira Hajiyan s hajiyan88@yahoo com Oct 9 2010 Department of Chemistry Isfahan University of Technology 84156 83111 Isfahan IranDegree M Sc Language FarsiSupervisor Prof A R Hajipour Email haji@cc iut ac irAbstractDue to the development of green chemistry in recent years researchers have been interested in theapplication of ionic liquids instead of common organic solvents Ionic liquids can also apply as greencatalysts Ionic liquid have remarkable properties such as non flammable high thermal stability negligiblevapor pressure easy recyclability and high solvating ability In addition acidic ionic liquids have madegood progress in this field and can widely use in organic reactions in the mild and efficient conditions Research in organic chemistry has expanded the one pot multi component reactions according to greenchemistry purposes In this work we report the application of 3 carboxypyridinium hydrogen sulfatereported as a green inexpensive and efficient acidic ionic liquid in the one pot multi component reactions Coumarins are widely used as drug and industrial materials We prepared here coumarins by Pechmanncondensation reaction This reaction is one of the most common procedures for the preparation of thesecompounds The coumarins were prepared by the various phenols and ketoesters in the presence of ionicliquid 3 carboxypyridinium hydrogen sulfate at 110 oC under solvent free conditions in high yields andshort reaction times 1 Amidomethyl 2 naphthols containing1 3 amino oxygenated functional groups applyas biological compounds at drugs such as nucleoside antibiotics and HIV protease inhibitors Thesecompounds can be prepared by multi component condensation of aryl aldehydes 2 naphthol andurea amides in acidic conditions by using 3 carboxypyridinium hydrogen sulfate under solvent freeconditions at 120 oC The reaction has many advantages such as high yields short reaction time easy work up and recyclability of the catalyst We also used 3 carboxy pyridinium hydrogen sulfate as an acid sourcein Strecker reaction for synthesis of aminonitriles by condensation reaction between three componentscontaining carbonyl compound ketone aldehyde amine and a cyanide source Aminonitriles areimportant precursors for the synthesis of amino acids and other biological molecules The reactions werecarried out under solvent free condition at ambient temperature with high yields in very short reactiontimes Keywords Green chemistry Acidic ionic liquid 3 Carboxy pyridinium Hydrogensulfate Coumarins 1 Amidomethyl 2 naphthols Aminonitriles

عبدالرضا حاجي پور

عبدالحسين دباغ، امير عبدالملكي