تهيه پلي اتيلن آنتي باكتريال و مطالعه شرايط فرآيندي بر ميزان رهايش آن

چكيده انگليسي :

110 Preparation of Antibacterial Polyethylene and Study of Processing Conditions on the Amount of Release Jamshid Kamalipoor j kamalipoor@ce iut ac ir Department of Chemical Engineering Isfahan University of Technology Isfahan Iran Degree M Sc Language Farsi Mahmood Masoomi supervisor mmasoomi@cc iut ac ir Hossein Ali Khonakdar supervisor h khonakdar@ippi ac ir Abstract Polymers have been widely used in different areas due to their ability to cover a broad spectrum of properties Polyethylene PE with antimicrobial properties is widely used in many industries e g food packaging industries medical instruments and building water tanks In polyethylene microbial contaminations are of main concern The application of antimicrobial agents into the polymer products is one of the methods to prevent the products from microbial contaminations Nowadays approaches that can endow polymers with anti infective properties mainly contain a mixing antibacterial reagents in bulk polymers b copolymerization of antibacterial reagents with monomer for polymers c surface modification of polymers In this study triclosan trichloro hydroxydiphenyl ether was used for preparation of antibacterial polyethylene compound Triclosan is a synthetic nonionic and broad spectrum antimicrobial agent Triclosan is an odorless tasteless and non toxic antibacterial agent displaying high chemical stability and persistent activity Its efficacy and safety in use have led to its wide use in such products as soaps deodorants toothpastes detergents lotions acne creams with a typical concentration in the range of and plastics Triclosan acts by blocking the active site of the enoyl acyl carrier protein reductase enzyme ENR which is an essential enzyme in fatty acid synthesis in bacteria By blocking the active site Triclosan inhibits the enzyme and therefore prevents the bacteria from synthesizing fatty acid which is necessary for building cell membranes for keeping the selective permeability and for reproducing Triclosan is a very potent inhibitor of ENR and only low concentrations are needed for powerful bactericidal action Humans do not have this ENR enzyme Two masterbatches with triclosan on the base of polyethylene and polyethylene grafted with maleic anhydride PE g MA were prepared by an internal mixer Then these masterbatches were diluted on the PE matrixes to and triclosan by a twin screw extruder The PE g MA was used for study of polymer matrix polarity on the triclosan release In order to study the effects of crystallization on the triclosan release the samples were cooled under three different cooling rates isothermal quench and a moderate cooling rate C min Biocide incorporated polymer films have been immersed in ethanol EtOH The release of triclosan from the polymer matrix was measured by UV Vis absorption spectroscopy for a period of time up to months The results showed that the samples which contained PE g MA had the highest triclosan release Moreover the samples which were cooled by quenching had the highest release of triclosan while the lowest release was belong to the samples that isothermally cooled Anti bacterial efficacy of medium density polyethylene MDPE with various concentrations of triclosan was considered The antibacterial properties of polyethylene that contain triclosan were evaluated according to ASTM E Plate Count Agar PCA methods was used for qualitative and quantitative analysis of the antibacterial properties using two gram positive bacteria Escherichia coli and Staphylococcus aureus and one gram negative bacteria Klebsiella pneumonia The results showed that triclosan is an efficient antibacterial agent for medium density polyethylene Samples that had been cooled by quenching showed the best most antibacterial properties while the samples that had been cooled

كمالي پور، جمشيد

تهيه پلي اتيلن آنتي باكتريال و مطالعه شرايط فرآيندي بر ميزان رهايش آن

تريكلوزان , پلي اتيلن پيوند زده شده با مالئيك انيدريد , كنترل رهايش , خواص ضد باكتري