6031

5640

كارشناسي ارشد

شيمي معدني

اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي

1389

ده،132ص.: مصور،جدول،نمودار

ص.ع.به فارسي و انگليسي

مهدي امير نصر، شادپور ملك پور

ثريا مقدادي

31/3/90

محمد حسين حبيبي، كاظم كرمي

شيمي

ID5640

به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي

131 Synthesis and Characterization of Co III Complexes with H2salabza as an Unsymmetrical Schiff base Ligand and H2Me2bpb as an Carboxamide Ligand and Investigation their Properties Fatemeh Karimi fkm024@gmail com March 8 2011 Department of Chemistry Isfahan University of Technology Isfahan 84156 83111 Iran Degree MSc Language Farsi Supervisor Prof M Amirnasr Email amirnasr@cc iut ac irAbstract The carboxamide C O NH group ubiquitous throughout nature in the primary structure ofproteins is an important ligand construction unit for coordination chemists However carboxamideshave anticancer and anti inflammatory activities There are several important biological and industrialapplication with amid functional group such as drug preparation pencilline and folic acid and dyesynthesis indigo On the other hand particular attention has recently been paid to the synthesis and study of diiminotetradentate Schiff base ligands and their complexes Interest in the design synthesis andcharacterization of transition metal complexes of unsymmetrical Schiff base ligands stems from thefact that the central metal ions in natural systems are unsymmetrical These complexes are used insome chemical processes as catalysts and also as biological models in understanding the structure ofbiomolecules and biological processes The coordination chemistry of cobalt is of considerable interest since cobalt II and cobalt III complexes derived from Schiff bases are reported to be biologically active Vitamin B12 which isinvolved in the production of red blood cells is a cobalt III complex with a substituted corrinmacrocycle Cobalt III complexes have shown specific hypoxic radiosensitization andthermosensitization as well as antitumor activity in vivo The antitumor action of cobalt III complexeswith tetradentate Schiff bases derived from aliphatic beta diketones and diamines was observed in thecase of ascite form of Erlich carcinoma Cobalt III schiff base complexes are found to be potentialantiviral agents On the other hand azide is a versatile ligand since it exhibits a variety of coordination modes such asmonodentate end on bridging mode 1 1 end to end bridging mode 1 3 etc among manyothers Azide acts as an inhibitor for several enzymes like ATPases So the study of metal azidocomplexes and especially Cobalt azide complexes with carboxamide or Schiff base ligands are veryuseful for the understanding of biological processes Therefore in this thesis we describe preparationof two kind of important cobalt III azide complexes In the first section we report the synthesis seven amide cobalt III azide complexes using tetradentateligand H2Me2bpb which may have biochemical and photochemical applications 1 Co Me2bpb prldn N3 H2O 2 Co Me2bpb pprdn N3 C2H5OH 3 Co Me2bpb mrpln N3 C2H5OH 4 Co Me2bpb 4 MePy N3 H2O 5 Co Me2bpb py N3 H2O 6 Co Me2bpb 4 AcPy N3 7 Co Me2bpb N MeIm N3 H2O In the second section we have used H2salabza as a Schiff bases ligand for the preparation of threecobalt III Azide complexes 8 Co salabza py N3 H2O 9 Co salabza 4 Mepy N3 10 Co salabza 4 AcPy N3

مهدي امير نصر، شادپور ملك پور

ثريا مقدادي

محمد حسين حبيبي، كاظم كرمي