پديد آورنده :
دوست محمدي، علي
عنوان :
تهيه و مشخصه يابي فيزيكي-شيميايي نانو ذرات بيو گلاس و ذرات هيدروكسي آپاتيت طبيعي و مقايسه رفتار زيستي اين مواد به روش نوين ميكرو/نانو گرما سنجي همدما
مقطع تحصيلي :
كارشناسي ارشد
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده مواد
صفحه شمار :
دوازده،136ص.: مصور،جدول،نمودار
يادداشت :
ص.ع.به فارسي و انگليسي
استاد راهنما :
احمد منشي، رسول صالحي
استاد مشاور :
محمد حسين فتحي، سعيد كرباسي، سعيد حبيبيان
توصيفگر ها :
ميكروگرماسنجي
تاريخ نمايه سازي :
21/6/90
استاد داور :
علي نعمتي، محمد رفيعي نيا، بتول هاشمي بني
كد ايرانداك :
ID384 دكتري
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
Preparation and Physico Chemical Characterization of Bioactive Glass Nanoparticles and Bone derived Hydroxyapatite Particles as well as Their Biological Evaluation by Isothermal Microcalorimetry Ali Doostmohammadi Alidstm@gmail com 2011 Department of Materials Engineering Isfahan University of Technology Isfahan 84156 83111 Iran Isfahan University of Medical Sciences Isfahan 81746 73461 Iran1st Supervisor Ahmad Monshi a monshi@cc iut ac ir2nd Supervisor Rasool Salehi r salehi@med mui ac ir1st Advisor Mohammad Hossein Fathi fathi@cc iut ac ir2nd Advisor Saeed Karbasi karbasi@med mui ac ir3nd Advisor Saeid Habibian Dehkordi Habibian dehkordi@yahoo comDepartment Graduate Coordinator Masoud Panjepour AbstractThis study aimed at preparing and comparing the physico chemical properties of bioactive glass and bone derived hydroxyapatite HA particles In addition in vitro cytotoxicity evaluation of bioglass nanoparticles HAparticles and bioglass HA mixture in similar weight percent with human chondrocyte cells was carried outusing isothermal micro nano calorimetry IMNC which is a new method for studying cell biomaterialinteractions For all three groups bioglass HA and bioglass HA mixture in vivo tests were carried out as well 63S bioglass particles were obtained by sol gel process and HA samples were derived from bovine bone Thechemical composition and the crystalline structure of both bioceramics were evaluated Then the zeta potential inphysiological saline and at different pH values was determined It was found that the negativity of zeta potentialfor 63S bioglass is higher than that of bone derived HA The IMNC results confirmed the viability growth andproliferation of human chondrocyte cells in contact with 63S bioactive glass and bone derived HA particles Nopositive effect for bioglass HA mixture was observed The results ofin vivo tests showed that bioglass and HAwere biocompatible and bioactive and can improve bone healing after 42 days implantation in rabbit tibia Inaddition an evident positive effect was observed for bioglass HA mixture The results confirmed that isothermalmicro nano calorimetry is a convenient method which caters to measuring the cell biomaterial interactionsalongside the current methods It was also concluded that bioglass HA mixture is more bioactive than bioglassand HA and therefore can be replaced for bioglass and HA in all their applications Keywords Bioglass Bone derived Hydroxyapatite Physico chemical properties Isothermal microcalorimetry Professor Department of Materials Engineering Isfahan University of Technology Isfahan Iran Associate Professor School of Medicine Isfahan University of Medical Science Isfahan Iran Associate Professor Department of Basic Sciences Faculty of Veterinary Shahrekord University Iran Assistant Professor Department of Materials Engineering Isfahan University of Technology Isfahan Iran 1
استاد راهنما :
احمد منشي، رسول صالحي
استاد مشاور :
محمد حسين فتحي، سعيد كرباسي، سعيد حبيبيان
استاد داور :
علي نعمتي، محمد رفيعي نيا، بتول هاشمي بني
