6512

6077

كارشناسي ارشد

شيمي پيشرفته

اصفهان: دانشگاه صنعتي اصفهان، دانشكده مهندسي شيمي

1390

سيزده، 115ص.: مصور، جدول، عكس، نمودار

ص.ع. به فارسي و انگليسي

محمد قريشي، مهدي پورمدني

علي اكبر دادخواه

3/12/90

مسعود حق شناس، مهرداد علي بوري

1396/10/12

كتابنامه

مهندسي شيمي

مهندسي شيمي

ID6077

به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي

116 Modeling of Nanomaterials Size Design and Production using Particles from Gas Saturated Supercritical Solutions Fateme Ahmadi Farsangi f ahmadifarsangi@cc iut ac ir Date of Submission 2011 7 9 Department of Chemical Engineering Isfahan University of Technology Isfahan 84156 83111 Iran Degree M Sc Language Farsi Supervisor Seyyed Mohammad Ghoreishi ghoreshi@cc iut ac ir Abstract Particles from Gas Saturated Solution PGSS is one of the supercritical fluid techniques for nanoparticles generation This process has different and unique advantages producing very fine particles with the same and narrow size distribution particle size controllability high purity of particle without solvent residue Modeling of this process helps the researchers to investigate the effects of important operating and design parameters on the nanoparticles size desi gn From available methods for nanoparticles generation by supercritical fluid Particles from Gas Saturated Solution was chosen for modeling because this method has some advantages in contrast to other methods Important advantages with respect to other methods are 1 this process requires lower pressure compare to Rapid Expansion of Supercritical Solution RESS 2 this method has lower consumption of gas compare to Supercritical Anti Solvent SAS because in this process there is lower ratio of gas in liquid 3 this process can generate particles without any solvent residue and 4 this process has the possibility of nanoparticles generation for encapsulated pharmacicual applications Main goals of this thesis was to model this process and model validation via comparison with experimental data Furthermore the validation model was used to investigate the effect of different design and operating variables on the particle size of the synthesis sized nanoparticles Moreover the parametric analysis of nanoparticle size design was carried out at the different operating range of effective variables In this thesis by comparing results of model with a particular experimental data pharmacicual nanoparticles of nifedipine the accuracy of model was checked Based on the input data given to the computer program the model predicted data had 1 3 error in contrast to experimental results The other reported models in the literature has higher error than the model of this study Thus this model was used to investigate the effect of different parameters such as pre expansion temperature pre expansion pressure nozzle diameter and heat flux on the average particle diameter and so we can use this model to know effect of dependent parameters to get profiles of thermodynamic profiles of thermodynamic properties along the nozzle and capillary Dependent on entrance conditions to nozzle average of particle diameter can be in the range of 20 23 m The obtained narrow particle size distribution is a normal Gaussian curve which coincide with experimental data Modeling results of Particles from Gas Saturated Solution showed that increasing the pre expansion temperature produced smaller particles because temperature is an effective parameter on the growth of particles The increasing pre expansion pressure led to the synthesis of smaller particles Modeling results of PGSS showed that heat flux of expansion device nozzle if driving process to adiabatic path led to smaller particles The modeling results show that increasing nozzle diameter led to larger particles so that small diameter of nozzle is appropriate suitable design condition Keywords modeling supercritical fluid nanoparticles nifedipine PGSS

محمد قريشي، مهدي پورمدني

علي اكبر دادخواه

مسعود حق شناس، مهرداد علي بوري