تهيه ارزيابي نانو الياف مخلوط آگار و پلي اكريلونيتريل حاوي متوتر كسات جهت رهايش كنترل شده دارو در درمان سرطان

چكيده انگليسي :

Production and evaluation of polyblend of agar and polyacrylonitrilenanofibers containing methotrexate for controlled drug release in cancer treatment Zahra Sadrearhami z sadrearhami@tx iut ac ir Jan 13 2013 Department of Textile Engineering Isfahan University of Technology Isfahan 84156 83111 IranDegree M Sc Language FarsiSupervisor s Name and Email address Dr Mohamad Morshed morshed@cc iut ac ir Dr Jaleh Varshosaz varshosaz@pharm mui ac ir Abstract For some years research into the eld of drug formulation has focused on the systems that delay the releaseof drugs from the substrate The reasons among others that have led to the formulation of sustained releasedrug delivery systems stem from the wish to achieve the slow release of highly water soluble compounds direct such compounds to the target organ or cell achieve release rates that match a given aim decrease thenumber of daily administrations and improve compliance and minimize side effects In this thesis polyblend of agar and polyacrylonitrile nanofibers containing methotrexate has beenelectrospun to be used for controlled drug release in cancer treatment To evaluate the effect of the polymerratio on release rate solutions with a fixed concentration of 15 polymer 6 drug and different polymersolution blends of polacrylonitrile agar ratios of 100 0 90 10 80 20 and 70 30 were prepared and thenanofibers were produced by electrospinning technique Also to evaluate the effect of the drug concentration solutions with concentrations of 0 6 12 and 18 of drug polymer weight ratio and constant ratio of twopolymers 90 10 was prepared were electrospun Scanning electron microscopy SEM was used toinvestigate the effect of polymer ratio and drug concentration on the morphology and average diameter of theelectrospun nanofibers The results showed that increasing the drug and agar percentage will lead to anincrease in the diameter due to an increased in the viscosity In order to study that no chemical intraction of thepolymer and drug has taken place FTIR spectrums were evaluated DSC results were also studied toinvestigate the physical structure and chemical interactions Drug release profiles were studied in phosphatebuffer solution PBS with pH 7 4 Spectrophotometric method was used to determine the drug release rate bymeasuring the concentration in the released phase The results suggested that increasing the drug concentration significantly increases the release rate After over 4 hours the amount of drug released from nanofibers with6 and 18 methotraxate concentrations was 26 4 and 79 8 respectively Also by increasing the agarratio in the solution blend mixture of polymers due to increase in the polarity and hydrophilic of drug deliverysystems the drug release rates were increased For example in a sample with no agar after 4 hours 9 91 andin a sample containing 30 agar 54 of the drug is released in the PBS According to the obtained results itcan be said that agar and poly acrylonitrile polyblend nanofibers can release methotrexate in a controlledmanner and the drug loaded nanofibers can be used as a locally controlled delivery system for methotrexate incancer treatment Also in this system by changing factors such as the percentage of drug or agar desiredrelease rate can be achieved Key Wordscontrolled drug release agar polyacrylonitrile nano fiber methotrexate

صدرارحامي، زهرا

تهيه ارزيابي نانو الياف مخلوط آگار و پلي اكريلونيتريل حاوي متوتر كسات جهت رهايش كنترل شده دارو در درمان سرطان