7841

7306

كارشناسي ارشد

شناسايي و انتخاب و روش ساخت مواد

اصفهان: دانشگاه صنعتي اصفهان، دانشكده مواد

1391

چهارده،86ص.: مصور،جدول،نمودار

ص.ع.به فارسي و انگليسي

محمدحسين فتحي، حسين ادريس

15/4/92

احمد منشي، رحمت اله عمادي

مهندسي مواد

ID7306

به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي

88 Fabrication and characterization of nanostructure forsterite hydroxyapatite composite foam for tissue engineering applications Mahsa Mohammadrezaie انگل سي m mohammadrezaie@ma iut ac ir Date of Submission 2013 03 11 Department of Materials Engineering Isfahan University of Technology Isfahan 84156 83111 Iran Degree M Sc Language Farsi Supervisor Mohammadhossein Fathi fathi@cc iut ac ir Hossein Edris h edris@cc iut ac ir Abstract In this study effort was focused on fabrication and characterization of nanostructure bioceramic composite foam For this purpose Hydroxyapatite HA and forsterite nanopowders were synthesized by sol gel and mechanochemical method respectively Nanostructure composite foams were prepared via addition of the HA to forsterite in proportion of 0 10 20 and 30 wt X ray diffraction XRD Scanning Electron Microscopy SEM Energy Dispersive Spectroscopy EDS and Transmission Electron Microscopy TEM were used to characterize and evaluate the phase structure crystallite size morphology size and distribution of the pores chemical composition and particle size of the prepared powders and nanostructure composite foams The porosity of the foams was measured by Archimedes method In order to evaluate the bioactivity and bioresorbability the prepared foams were immersed in the simulated body fluid SBF for 28 days The concentration of the calcium and phosphorous ions in the filtered solutions were determined by inductive coupled plasma optical emission spectroscopy ICP OES XRD and SEM were used to investigate the bone like apatite formation on the surface of the foams and pores filling by formation of apatite The results showed that the foams have a grain size smaller than 50 nm and pore size is in the range 60 400 m The compressive strength and elastic modulus of the foams decreased with increasing of HA The maximum values of compressive strength and elastic modulus of the foams were found to be about 7 2 MPa and 0 271 GPa respectively which are close to the lower limit of the compressive strength and elastic modulus of cancellous bone The mean values of true and apparent porosity were calculated in the range 77 87 and 66 79 respectively In vitro tests showed the high bioactivity and resorbability of the foams The obtained foams have similar chemical composition to the mineral phase of bone and by changing the ratio of HA forsterite can approach the appropriate bioactivity and biodegradability level needed for different medical applications Considering the obtained results it seems that the manufactured foams could be a good candidate for tissue engineering applications such as drug delivery and cell loading However cell culture and in vivo tests are needed for more assurance Keywords Forsterite Hydroxyapatite Gelcasting Nanostructure composite Foam PDF created with pdfFactory trial version www pdffactory com

محمدحسين فتحي، حسين ادريس

احمد منشي، رحمت اله عمادي