پديد آورنده :
اسماعيلي، ميلاد
عنوان :
سنتز و بررسي ساختار كمپلكس هاي فلزي مس و روي با داروهاي ضد درد غير استروييدي و بررسي خاصيت آنتي باكتريايي آنها
مقطع تحصيلي :
كارشناسي ارشد
گرايش تحصيلي :
شيمي معدني
محل تحصيل :
اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي
صفحه شمار :
[ده]،81ص.: مصور،جدول،نمودار
يادداشت :
ص.ع.به فارسي و انگليسي
استاد راهنما :
حسين چيني فروشان
استاد مشاور :
محمدرضا سبزعليان
تاريخ نمايه سازي :
1/11/92
استاد داور :
غلام حسين محمدنژاد، حسين كيانفر
چكيده فارسي :
به فارسي و انگليسي: قابل رويت در نسخه ديجيتالي
چكيده انگليسي :
The non steroidal anti inflammatory drugs metal complexes of Cu II and Zn II synthesis structure and antibacterial activity Milad Esmaeili Milad esmaeili@ch iut ac ir Date of Submission 2013 15 09 Department of Chemistry Isfahan University of Technology Isfahan 84156 83111 Iran Degree M Sc Language FarsiSupervisor Hosseine Chiniforooshan chinif@cc iut ac irAbstractIn this thesis Cu II and Zn II metal complexes with the non steroidal anti inflammatorydrugs mefenamic acid and diclofenac sodium have been synthesized and characterized in thepresence of nitrogen donor ligand isothiocyanate mefenamic acid and diclofenac sodium actas deprotonated ligands coordinated to metal ions through carboxylato oxygens Thecomplexes were identified and fully characterized by elemental analysis and spectroscopicstudies IR 1H NMR and UV vis Non steroidal anti inflammatory drugs NSAIDs areamong the most frequently used medicinal drugs used as analgesic anti inflammatory andantipyretic agents Additionally NSAIDs have exhibited chemopreventive and anti tumorigenic activity by reducing the number and size of carcinogen induced colon tumors andexhibiting a synergistic role on the activity of certain antitumor drugs Mefenamic acid Hmef and sodium diclofenac Nadicl belong to the NSAID group of phenyl alkanoic acids Theyexhibit favourable anti inflammatory analgesic and antipyretic properties In this work we have designed and synthesized new Cu II and Zn II complexes The IRspectra of all complexes show a strong absorption due to the isothiocyanate Ligand Theelemental analysis results of the prepared compounds are in a good agreement with thecalculated values On the other hand the aim of this paper is to synthesize new Cu II metalcomplexes and in vitroresearch of their antibacterial activities The synthesis and evaluation ofthe biological activity of the new metal based compounds is the field of growing interest Thecomplexes were tested for in vitro growth inhibitory activity against Escherichia coli andBacillus thuringiensis were found to possess significant Activity Keywords non steroidal anti inflammatory drugs Mefenamic acid sodium diclofenac antibacterial activity
استاد راهنما :
حسين چيني فروشان
استاد مشاور :
محمدرضا سبزعليان
استاد داور :
غلام حسين محمدنژاد، حسين كيانفر
