9629

724 دكتري

دكتري

شيمي تجزيه

اصفهان: دانشگاه صنعتي اصفهان، دانشكده شيمي

1393

هفده،124ص.: مصور،جدول،نمودار

ص.ع.به فارسي و انگليسي

بهزاد رضايي

علي اصغر انصافي، محمد سراجي

93/12/18

تقي خياميان،محمدتقي جعفري،مسعود آيت اللهي مهرجردي

شيمي

ID724 دكتري

Development and characterization of new coated surface with micro and nano structured polymer for solid phasemicroextraction and electrochemical sensors based on molecularly imprinted polymers MaliheKhaliliBoroujeni m boroujeni@ch iut ac ir Department of Chemistry Isfahan University of Technology 84156 83111 Isfahan IranSupervisor Professor B Rezaei E Mail Rezaei@cc iut ac irAdvisors Professor A A Ensafi and Professor M SarajiAbstract In this thesis some novel preparation methods based on solid absorbents combined with variousdetermination techniques gas chromatography and voltammetry were developed Novel composites andnanocomposites were introduced to improve the preparation methods and extend the application of solidabsorbents In the first part a novel solid phase microextraction ber coated with polypyrrole sol gel composite wasprepared through electrochemical deposition The SPME composite coating was evaluated by analyzing someorganophosphorus pesticides in water and vegetable samples followed by gas chromatography and nitrogenphosphorus detection The calibration curves were linear in the concentration range from 5 to 2000 ng L 1 R2 0 9953 and the detection limits were 1 5 10 ng L 1 Relative standard deviations for intra and inter day precisionfor a single fiber were in the range of 1 1 2 9 and 2 2 4 2 respectively Fiber to fiber reproducibility were inthe range of 6 0 10 1 n 3 Finally the developed method was applied to the analysis of cucumber lettuce tapand well water samples and the relative recovery were found to be in the range of 80 109 at the optimumconditions In the second part a novel sensitive and selective imprinted electrochemical sensor composed fromconductive polymer sol gel and AuNPs for the indirect determination of caffeine has been prepared The linearrange of the imprinted sensor were in the concentration range from 2 to 50 and 50 to 1000 nmol L 1 with thedetection limit of 0 9 nmol L 1 S N 3 Furthermore the proposed method was successfully intended for thedetermination of caffeine in real samples tablet green tea energy and soda drink In the third part the method presented in the previous study was used for determination of lorazepam in realsamples tablet plasma and urine Under the optimized condition the linear range of the imprinted sensor werein the concentration range from 0 2 to 2 and 2 to 20 nM with the limit of detection LOD of 0 085 nM S N 3 In the fourth part A new type of molecularly imprinted polymer ds DNA and gold nanoparticles wereelectrochemically entrapped into poly o phenylenediamine polymer network sensor was synthesized through anefficient one step electropolymerization technique The square wave voltammetric peak current was linear toSudan II concentration in the range of 1 0 to 20 0 and 20 0 to 500 0 nmol L 1 with a detection limit of 0 3 nmolL 1 The sensor was applied successfully for the determination of Sudan II in chili and ketchup sauces withsatisfactory precision 2 6 4 4 of RSD and acceptable recoveries 90 107 demonstrating its feasibility forpractical application In the last part the method presented in the previous study was used for determination of dopamine in realsamples plasma and urine Differential pulse voltammetry was applied as a sensitive analytical method for thedetermination of dopamine and a good linear relationship between dopamine concentration and peak current wasobtained within the range of 20 7000 nM with a detection limit of 6 nM

بهزاد رضايي

علي اصغر انصافي، محمد سراجي

تقي خياميان،محمدتقي جعفري،مسعود آيت اللهي مهرجردي