Descriptors :
Bovine Serum Albumin , Antioxidant , Nanoparticles , Quercetin
Abstract :
Quercetin is a flavonoid reported as anti-allergic, anti-inflammatory, antiplatelet, anti-microbial,
antioxidant, antineurodegenerative and antitumoral. However, due to its low water solubility, its efficacy
is restricted. Nanotechnology can be an importante tool to improve the quercetin properties
and increase its bioavailability. In this study, bovine serum albumin (BSA) nanoparticles containing
quercetin were developed by desolvation technique, characterized the mean particle size, polydispersity,
zeta potential, encapsulation efficiency, physical state of drug in nanoparticles and drug
release profile as well as their antioxidant activity was evaluated. The influence of glutaraldehyde
percentage in nanoparticles properties was evaluated and did not influence the nanoparticles
parameters. Nanoparticles presented a mean size around 130 nm and encapsulation efficiency
around 85%. Results from X-ray diffractometry showed that the crystal of the drug was converted
to an amorphous state in polymeric matrix. Quercetin release profile demonstrated a biphasic pattern
and after 96 h approximately 18% of drug was released. Kinetic models demonstrated that the
quercetin release followed a second-order model and the release was governed by Fickian diffusion.
After 96 h, quercetin-loaded nanoparticles were more effective than free quercetin for scanvenger of
radical ABTS·+ and hypochlorous acid. BSA nanoparticles represents potential carriers for improve
quercetin properties.
Author/Authors :
Antçnio, Emilli , Khalil, Najeh Maissar , Mainardes, Rubiana Mara
