1137

2017

362-372

Journal of Molecular Structure

pdf

In the first part of this paper, docking method was employed in order to study the binding mechanism of breast cancer resistance protein (BCRP) with a group of previously synthesized TPS-A derivatives which known as potent inhibitors of this protein to get insight into drug binding site of BCRP and to explore structureeactivity relationship of these compounds. Molecular docking results showed that most of these compounds bind in the binding site of BCRP at the interface between the membrane and outer environment. In the second part, a group of designed TPS-A derivatives which showed good binding energies in the binding site of ab-tubulin in the previous study were chosen to study their binding energies in the binding site of BCRP to investigate their simultaneous inhibitory effect on both ab-tubulin and BCRP. The results showed that all of these compounds bind to the binding site of BCRP with relatively suitable binding energies and therefore could be potential inhibitors of both ab-tubulin and BCRP proteins. Finally, virtual consensus docking method was utilized with the aim of design of new 2,5 diketopiperazine derivatives with significant inhibitory effect on both ab-tubulin and BCRP proteins.For this purpose binding energies of a library of 2,5-diketopiperazine derivatives in the binding sites of ab-tubulin and BCRP was investigated by using AutoDock and AutoDock vina tools. Molecular docking results revealed that a group of 36 compounds among them exhibit strong anti-tubulin and anti-BCRP activity.

EA 5

1397/09/27

Dashagha

5